Abstract Introduction: Sex education is one of the basic pillars of human development because it enhances people’s autonomy and the development of full sexuality. Objective: This study sought to describe the perception regarding sex education of adolescents from two educational establishments in Talcahuano, Chile. Method: A cross-sectional descriptive study was conducted with 309 students from two schools located in the Talcahuano Commune, Bío-Bío region, Chile. A self-report questionnaire was applied in person. Data were analyzed using IBM Statistics SPSS v.22 software. Results: 61.8% reported receiving sex education in their establishment and almost all considered it necessary to learn about it. 52.7% reported that their establishments generated instances to talk about sexuality. In relation to the topics that should be included in sex education, “Values, respect, ethics”, “Contraceptives and prevention of sexually transmitted infections” and “Love and affectivity” were the most preferred. Conclusion: Despite the existence of instances of sex education in educational establishments, and the transversal opinion that it is necessary to learn about this subject, there is a low perception regarding its adequacy.

Resumen Introducción: La educación sexual es uno de los pilares básicos del desarrollo humano por cuanto potencia la autonomía de las personas y el desarrollo de una sexualidad plena. Objetivo: Este estudio buscó describir la percepción respecto a la educación sexual de adolescentes de dos establecimientos educacionales de Talcahuano, Chile. Método: Se realizó un estudio de corte transversal de carácter descriptivo con 309 estudiantes de dos colegios ubicados en la Comuna de Talcahuano, región del Bío-Bío, Chile. Se aplicó de forma presencial un cuestionario de autorreporte. Los datos fueron analizados mediante el software IBM Statistics SPSS v.22. Resultados: El 61,8% reportó recibir educación sexual en su establecimiento y casi la totalidad consideró necesario aprender sobre ello. Un 52,7% refirió que sus establecimientos generaban instancias para hablar de sexualidad. En relación con las temáticas que deberían ser incluidas en la educación sexual, «Valores, respeto, ética», «Anticonceptivos y prevención de infecciones de transmisión sexual» y «Amor y afectividad» fueron las más preferidas. Conclusión: Pese a la existencia de instancias de educación sexual en los establecimientos educacionales y a la transversal opinión de que es necesario aprender sobre este tema, existe una baja percepción respecto a su suficiencia.

Resumen Los riesgos teratogénicos ocasionados por la exposición intrauterina a fármacos antiepilépticos (FAE) son conocidos, por lo que su prescripción se mantiene bajo estricto control. Describir los efectos adversos fetales de la exposición a FAE durante la gestación, reportados en la literatura durante el período 2016-2022. Revisión sistematizada de estudios que reportaron los efectos adversos fetales inducidos por la exposición a FAE en mujeres embarazadas en tratamiento por diagnósticos neurológicos, principalmente de epilepsia. La búsqueda se realizó en PubMed, Cochrane, Web of Science, SCOPUS, Biblioteca Virtual en Salud, Lilacs y SciELO. Se identificaron 37 artículos distribuidos en 13 países de Asia, Europa, América del Norte y Oceanía. Se observaron resultados perinatales adversos, tanto físicos como cognitivos, en la mayoría de los estudios. Los fármacos identificados como los más utilizados en los últimos años fueron valproato, topiramato, carbamazepina, lamotrigina y levetiracetam. Los FAE tienen potencial teratogénico en distintos grados de riesgo, provocando anomalías congénitas o efectos adversos en múltiples sistemas del cuerpo humano, siendo los sistemas nervioso, circulatorio y osteomuscular los más afectados.

Abstract The teratogenic risks caused by intrauterine exposure to antiepileptic drugs (AED) are known, so their prescription is kept under strict control. To describe the fetal adverse effects AED exposure during gestation, reported in the literature during the period 2016-2022. Systematized review of studies that reported fetal adverse effects induced for the exposure to AED in pregnant women in treatment for neurological diagnoses, mainly epilepsy. The search was carried out in PubMed, Cochrane, Web of Science, SCOPUS, Virtual Health Library, Lilacs and SciELO. 37 articles distributed in thirteen countries in Asia, Europe, North America and Oceania were identified. Adverse perinatal outcomes, both physical and cognitive, were observed in most studies. The most common drugs identified were valproate, topiramate, carbamazepine, lamotrigine and levetiracetam. AED have teratogenic potential in different degrees of risk, causing congenital anomalies or adverse effects in multiple systems of the human body, being the nervous, circulatory and musculoskeletal systems the most affected.

Abstract Objective: To explore the perception of women of reproductive age regarding delivery routes reported in the available evidence. Method: A systematized review of articles in PubMed, SciELO, SCOPUS, Web of Science, LILACS, Cochrane Library, Biblioteca Virtual de Salud databases, was carried out. The search was conducted between August and November 2020. MeSH descriptors “Perception”, “Delivery Obstetric”, “Cesarean Section” and “Woman”, along with DECS descriptors “Percepciones”, “Parto Obstétrico”, “Cesárea” and “Mujeres”, were used. Also, free terms “Perceptions”, “Vaginal Delivery”, “Obstetric Deliveries”, “Abdominal Deliveries”, “Caesarean Section” and “Women’s Groups”. In the totality of databases limits of search “Last 5 years” and “Free Full Text”, were used. Results: Regarding the perception of the delivery routes, the preference of the vaginal route over caesarean section was verified. In addition, factors that influence the process such as fear, previous experience, influence of third parties, religion, culture, socioeconomic level and demographic area were evidenced. Conclusions: The reviewed evidence suggests that women prefer the vaginal delivery route over caesarean section with fear being the most influential factor at the time of their choice, and secondly, the factors associated with previous experiences, socioeconomic level and beliefs.

Resumen Objetivo: Explorar la percepción de mujeres en edad reproductiva con respecto a las vías del parto reportada en la evidencia disponible. Método: Se llevó a cabo una revisión sistematizada de artículos en las bases de datos PubMed, SciELO, SCOPUS, Web of Science, LILACS, Cochrane Library y Biblioteca Virtual de Salud. La búsqueda se realizó entre agosto y noviembre del año 2020. Los términos MeSH usados fueron “Perception”, “Delivery Obstetric”, “Cesarean Section” y “Woman”, junto con los términos DECS “Percepción”, “Parto Obstétrico”, “Cesárea” y “Mujeres”. Además, se utilizaron los términos libres “Perceptions”, “Vaginal Delivery”, “Obstetric Deliveries”, “Abdominal Deliveries”, “Caesarean Section” y “Women’s Groups”. En la totalidad de las bases de datos utilizadas se aplicaron como límites de búsqueda “Last 5 Years” y “Free Full Text”. Resultados: Respecto a la percepción de las vías de parto, se constató la preferencia de la vía vaginal sobre la cesárea. Además, se evidenciaron factores que influyen en el proceso, tales como miedo, experiencia previa, influencia de terceros, religión, cultura, nivel socioeconómico y zona demográfica. Conclusiones: La evidencia revisada sugiere que las mujeres prefieren la vía del parto vaginal sobre la cesárea, siendo el miedo el factor más influyente al momento de su elección, seguido por los factores asociados a experiencias previas, el nivel socioeconómico y las creencias.

Background: Therapeutic Plasma Exchange (TPE) is a procedure in which plasma and harmful macromolecules are separated from the rest of the blood components by centrifugation or filtration through membranes and are replaced with solutions with albumin and/or plasma. Aim: To communicate our experience using TPE by filtration. Material and Methods: Review of records of 655 TPE sessions performed in 102 patients aged 50 ± 18 years (64% women). The requirement of renal replacement therapy (RRT) and seven days and one year mortality were recorded. Results: Forty five percent of patients had hypertension or diabetes. The main indications for TPE were pulmonary-renal syndrome (PRS) (62%) and antibody mediated graft rejection (29%), followed by neurological diseases (36%). Fifteen percent of patients required RRT for one year. Mortality at seven days and one year was 20 and 30%, respectively. Out of the total of deaths associated with kidney diseases, 88% corresponded to PRS and ANCA vasculitis. The main complications were thrombocytopenia in 41%, hypocalcemia in 18%, and hypotension in 16%. Conclusions: In our experience, TPE by filtration is a safe technique, with mild and preventable complications. Despite this, the reported mortality is high, which reflects the severity of the diseases that motivated the indication for TPE.

Abstract Background: Sleep is a critical physiological state, which occurs with loss of consciousness and response capacity. During this, essential processes for learning and metabolism are carried out, so it is important to preserve adequate sleep quality. Aim: To describe the sleep quality of medical students at Andrés Bello University, Concepción headquarter, during the first half of 2019. Methods: A descriptive cross-sectional study was carried out with 147 students from the first to fourth year of the medical career at Andrés Bello University, Concepción headquarter. Data was collected using the Pittsburgh Sleep Quality Index --ICSP--, and later processed with IBM Statistics SPSS v.22 software. Results: 91,8% of students showed poor sleep quality (ICSP> 5), with average score of 8,4. Components with mayor variability between courses were duration (p<0,01) and sleep disturbances (p<0,02). For their part, students who were working had mayor presence of sleep disturbances compared to those who only dedicated themselves to their studies (p=0,03). Conclusions: The surveyed students reported poor sleep hygiene. This could be attributed to the high academic demand and / or the time load used in theoretical and practical classes, and it would be made worse by adding additional demands such as having to work during studies. As a future projection, longitudinal follow-up of the students would be recommended, which would allow evaluating the impact that different variables such as stress, evaluations, variations in the number of subjects and semester clinical hours, among others, would have on the sleep quality of the students. MED.UIS.2021;34(3): 29-38.

Resumen Introducción: El sueño es un estado fisiológico-rítmico que cursa con pérdida de conciencia y capacidad de respuesta. Durante este se llevan a cabo procesos imprescindibles para el aprendizaje y el metabolismo, por lo que cobra relevancia conservar una adecuada calidad del mismo. Objetivo: Describir la calidad del sueño de los estudiantes de medicina de la Universidad Andrés Bello sede Concepción, durante el primer semestre del año 2019. Métodos: Se realizó un estudio descriptivo de corte transversal con 147 estudiantes de primer a cuarto año de la carrera de medicina de la Universidad Andrés Bello sede Concepción. Los datos fueron levantados mediante el Índice de la Calidad de Sueño de Pittsburgh --ICSP--, y posteriormente procesados con el software IBM Statistics SPSS v.22. Resultados: El 91,8% de los estudiantes presentaron mala calidad de sueño (ICSP>5), con una puntuación promedio de 8,4. Los componentes con mayor variabilidad entre los cursos fueron la duración (p<0,01) y las perturbaciones del sueño (p<0,02). Por su parte, los estudiantes que trabajaban presentaron mayor presencia de perturbaciones del sueño en comparación con aquellos que solo se dedicaban a sus estudios (p=0,03). Conclusiones: Los estudiantes de la carrera de medicina de la Universidad Andrés Bello, sede Concepción, presentaron una mala calidad del sueño. Esto podría ser atribuido a la alta exigencia académica y/o a la carga horaria utilizada en clases teóricas y prácticas, y empeoraría al agregar exigencias adicionales como tener que trabajar durante los estudios. MÉD.UIS.2021;34(3): 29-38.

ABSTRACT Background Given that knowledge about emergency contraception can be very useful in promoting sexual health and reproductive health, especially in adolescents, its deficiency could decrease its prescription and use. Aim To describe the knowledge about emergency contraceptive methods of a group of female adolescent secondary education students from the Hualqui commune, Chile. Method A descriptive cross-sectional study was carried out. 115 adolescent women students from first to fourth year of high school at San Juan Bautista high school in Hualqui, Eighth Region of Chile, were surveyed. General sexual health and reproductive health backgrounds, and knowledge of emergency contraception, its use, and forms of acquisition were explored. Results The average age was 16,1 years. 39% of the students were sexually active, and on average started their sex life at 15,3 years and had 2,1 sexual partners. The most widely used contraceptive method was injectable hormonal contraception (31,1%), followed by combined oral contraception (20,0%). Regarding the emergency contraception, 80,9% stated that they knew of their free delivery, while 11,1% stated that they had ever used them. 91,3% of respondents considered it necessary to have more information. Conclusions The adolescents participating in the study showed some degree of knowledge regarding emergency contraception, despite not using it regularly. However, the majority expressed the need for greater access to information related to the topic.

RESUMEN Introducción Dado que el conocimiento sobre la anticoncepción de emergencia puede ser de gran utilidad en la promoción de la salud sexual y salud reproductiva, especialmente en los adolescentes, la deficiencia del mismo podría disminuir su prescripción y uso. Objetivo Describir el conocimiento sobre los métodos anticonceptivos de emergencia de un grupo de mujeres adolescentes estudiantes de enseñanza media de la comuna de Hualqui, Chile. Material y método Se realizó un estudio descriptivo de corte transversal. Se encuestó a 115 mujeres adolescentes estudiantes de primer a cuarto año de enseñanza media del liceo San Juan Bautista de Hualqui, Octava Región de Chile. Se exploraron antecedentes generales de salud sexual y salud reproductiva, y conocimientos sobre la anticoncepción de emergencia, su uso y formas de adquisición. Resultados La edad promedio fue de 16,1 años. El 39% de las estudiantes eran sexualmente activas, y en promedio iniciaron su vida sexual a los 15,3 años y tuvieron 2,1 parejas sexuales. El método anticonceptivo que más utilizaban fue el anticonceptivo hormonal inyectable (31,1%), seguido de la anticoncepción oral combinada (20,0%). Con respecto a la anticoncepción de emergencia, el 80,9% declaró saber de su entrega liberada, mientras que el 11,1% declaró haberlos usado alguna vez. El 91,3% de las encuestadas consideró necesario tener mayor información. Conclusión Las adolescentes participantes del estudio mostraron algún grado de conocimiento respecto a la anticoncepción de emergencia, pese a no utilizarla habitualmente. No obstante, la mayoría expresó la necesidad de tener mayor acceso a información relacionada al tema.

Abstract: The quality of life is a relevant issue in the context of higher education in Chile. This work sought to characterize the quality of life of students of different levels of the Medicine program in Andrés Bello University, Concepción campus, Chile. A descriptive cross-sectional study was conducted in which 159 students, whose ages ranged from 18 to 25 years, answered the WHOQOL-BREF questionnaire. Within the findings of this study, a general perception of positive quality of life was found (45,57% considered it quite good). When analyzing the domains of WHOQOL-BREF, it was found that women reported lower values than men in physical health, social environment and psychological health, the latter being the worst qualified in both sexes, suggesting that psychological wellbeing is relatively deficitary. It was concluded that the students had a good perception of quality of life, however, sex was a variable that influenced their perception.

Resumen: La calidad de vida es un tema relevante en el contexto de la educación superior de Chile. Este trabajo buscó caracterizar la calidad de vida de los estudiantes de los distintos niveles de la carrera de Medicina de la Universidad Andrés Bello, sede Concepción, Chile. Se realizó un estudio descriptivo de corte transversal en el que 159 estudiantes, cuyas edades fluctuaron entre 18 y 25 años, respondieron el cuestionario WHOQOL-BREF. Dentro de los hallazgos de este estudio, se encontró una percepción general de calidad de vida positiva (45,57% la consideró bastante buena). Al analizar los dominios del WHOQOL-BREF, se encontró que las mujeres reportaron valores más bajos que los hombres en salud física, entorno social y salud psicológica; esta última fue el aspecto peor calificad en ambos sexos, sugiriendo que el bienestar psicológico es relativamente deficitario. Se concluyó que los estudiantes tenían una buena percepción de calidad de vida, no obstante, el sexo fue una variable que influyó en la percepción de esta.

Background: The treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is based on corticosteroids, immunoglobulin and plasmapheresis. In our Health System, corticosteroids are commonly used as first line therapy for economic reasons and accessibility. However, the factors associated with a good response are not well known. Aim: To assess the association of demographic, clinical and laboratory variables with a favorable response to corticosteroid therapy in patients with CIDP. Material and Methods: Observational, descriptive, longitudinal and retrospective study of 33 patients with a diagnosis of typical, definitive or probable CIDP, treated with corticosteroids for at least six months. Results: Twenty-three patients had a good clinical response to corticosteroid treatment and 10 were non-responders. The variables significantly associated with a good response to steroids were a disease lasting less than 1 year prior to the start of treatment, the absence of axonal damage in electromyography a relapsing-recurrent course and a favorable response within two months of treatment. Conclusions: Most of these patients with CIDP had good response to corticosteroid therapy.

Background: Postmenopausal women have higher severity of coronary heart disease (CHD) than premenopausal women and type 2 diabetes mellitus (T2DM) is an independent risk factor. Aim: To assess the severity of CHD in pre and postmenopausal patients undergoing coronary angiography and the impact of T2DM in both groups. Material and Methods: A coronary angiography was performed to 707 women due to suspected CHD during 2013 and 2014. Of these, 579 were older than 55 years and were considered as postmenopausal. Factors such as hypertension, obesity, smoking, creatinine and T2DM were registered. The severity of CHD in coronary angiography was evaluated according to the number of vessels with more than 50% stenosis. Results: Compared to their postmenopausal counterparts, premenopausal women had less frequency of T2DM (31% and 42% p < 0.033), hypertension (52 and 78%, p < 0.001) and alteration of renal function (11 vs. 39%, p < 0.001). Absence of coronary lesions was found in 44 and 32% of premenopausal and postmenopausal women, respectively (p < 0.01). Premenopausal women with T2DM had a higher frequency of multi-vessel disease than those without the disease (25 and 4.5%, p < 0.001). The frequency of multi-vessel disease was higher in postmenopausal than premenopausal women (24 and 11%, p < 0.01). Hypertension, T2DM and renal involvement were associated with a higher frequency multiple vessel disease. Conclusions: The severity of CHD is higher in postmenopausal women and T2DM is associated with the disease.

Renal papillary necrosis is an infrequent cause of hematuria characterized by ischemic necrosis of the renal medulla, especially the papilla. Its most common cause is analgesic abuse. Despite being oligo-symptomatic, in many cases its presence is associated with serious functional sequelae. Imaging, especially computed tomography, is essential to make the diagnosis. We report a 63-year-old female studied for an asymptomatic microscopic hematuria whose tomographic study showed a bilateral renal papillary necrosis. No etiology was found, and she evolved with a spontaneous complete remission.

Background Affordable interventions to improve metabolic control of Type 2-Diabetes Mellitus are increasingly necessary. Aim To review systematically the existing literature on the effects of psychological interventions on Type-2 Diabetes Mellitus compensation. Material and Methods We performed a systematic literature review and meta-analysis on the effectiveness of psychological interventions implemented for Type-2 Diabetes Mellitus patients. Research included the following electronic databases: PubMed, Bireme, Web of Science, SciELO, Embase, EBSCOhost, SCOPUS, Psychology Database. Results Most studies showed a decrease in the level of glycated hemoglobin after interventions, which applied different initiatives complementary to standard medical treatment. Mainly, these interventions encompassed training for self-monitoring and control of diabetes based on cognitive behavioral psychology, counseling, self-assessment and physical-spiritual work based on transpersonal psychology. Conclusions Psychological tools could be an adjunct to the standard medical treatment for patients with Type-2 Diabetes Mellitus, reducing glycated hemoglobin levels and improving self-regulation, disease awareness and adherence from the self-efficacy perception perspective.

Chronic kidney disease is associated with an increase in cardiovascular risk and mortality, and a decrease in the health-related quality of life. It is known that the physical capacity of patients with chronic kidney disease is lower than their healthy counterparts. It also decreases progressively after the start of hemodialysis, even leading to the loss of functional independence. There is a positive association between exercise and improvement of many targets in chronic kidney disease, especially in dialysis patients, such as cellular apoptosis, immune improvement and inflammation. In addition, several clinical studies and systematic reviews show an improvement in different clinical and laboratory variables and suggest a lower mortality, proving a reduction of health care economic costs. Exercise intervention in dialysis is safe. Although different guidelines promote exercise, it is necessary to work on its implementation on a large scale.

Background: Exclusive coronary revascularization with both mammary arteries could result in lower rates of adverse events in the long term. Aim: To describe the five-year evolution of a cohort of patients operated on with this technique. Material and Methods: Follow up analyzing survival of 73 patients aged 59 ± 9 years (82% men) who underwent exclusive coronary surgery with two mammary arteries between December 1,2010 and April 12,2017. We studied their clinical characteristics, surgical results, operative morbidity and mortality and adverse events up to June 30, 2018. Results: Six patients had two-vessel lesions and 67 three-vessel lesions. The operative risk calculated by additive and logistic EuroSCORE was 2.5 and 2.3%, respectively. A mean of 3.75 anastomoses /patient were performed, 116 with left mammary artery (73 to the anterior descending artery, 38 to a diagonal artery and 5 for other objectives) and 158 with right mammary artery (69 to a first marginal artery, 23 to a second marginal artery and 64 to posterior descending artery). There was one case of mediastinitis and one (1.5%) patient died. The mean follow-up was 64.6 ± 23.7 months. The 5-year survival was 90.4%. Conclusions: Coronary revascularization with two exclusive mammary arteries allowed a complete revascularization of the heart with a low rate of complications and adverse effects at five years.